This collection consists of legal documents, business records and stock shares from the career of John C. Moore, his descendants, and the John C. Moore Company. The materials in the collection date between 1864 and 1951.

Records of a Rochester flour mill include daybooks, ledgers, journals, cash books, ledgers, wheat purchase books, shipping books, sales records, order books, time books, and miscellaneous records of the last flour milling firm in Rochester.

This collection consists of the records of Moses and William R. Seward, father and son. Moses B. Seward was a mill owner and local political figure, while William R. was active in banking and a leading philanthropist. The collection dates from 1799 to 1901, and includes letters, bills, legal and real estate documents, a ledger book and financial records.

This is an artificial collection consisting of printed sheet music and scores, most but not all associated with Rochester, New York. Most appear to come from older materials held by the Rochester Public Library and transferred to the Local History Division for preservation. The materials date between 1843 and 1964.

Diary of Myra B. Fox for the year 1877. According to the donor, Miss Fox was a resident of Violetta Street. However, a search of census records suggests that she actually lived in Moravia, Cayauga County at that time, and later moved to Rochester.

This collection consists of the personal papers of Nancy Ann Howes and the papers of the CD (Crossdresser) Network, a support and social group for crossdressers located in Rochester, New York. The materials date between 1964 and 2017 with the bulk dating between 1987 and 2004. The materials are comprised of essays, correspondence, pamphlets, magazines, books, news clippings, ephemera, newsletters, photographs, scrapbooks, and sketchbooks.

This collection consists of the records of Nathaniel and Jesse Shepard, father and son, of West Bloomfield, Ontario County, New York. The records consist of letters, deeds and accounts. They date from 1796 to 1876.

The National League for Woman's Service was a patriotic organization that provided training and leadership for women's efforts to support the war effort during World War One across the United States. This collection includes enrollment forms, correspondence, and program information along with service registration forms from residents of Fairport, Rochester, Honeoye Falls. The materials date from 1916 to 1919.

Three record books from the Needlework Guild, a charitable group that provided clothing for the needy in Rochester, New York. The books date between 1893 and 1930.

Consists of equipment return and other documents from the NY 8th cavalry.

This collection consists of the records of Obed Hussey, inventor of an early mechanical reaper. The materials date between 1833 and 1916, with the bulk of the material dating between 1852 and 1858. The materials include letters, trade catalogs, advertising images, and popular magazines.

This collection consists of the records created during daily activities of past Rochester City Historians, Joseph Barnes, Edward Foreman, Blake McKelvey, and Ruth Rosenberg-Naparsteck. The materials date between 1818 and 2007. The records consist of correspondence, special projects, publications, events, and subject research files.

This collection consists of the records of Open Arms Metropolitan Community Church, a religious organization serving the LGBTQ+ community of Rochester, New York. The materials date between 1981 and 2023. The records are comprised of administrative and legal documents, contracts, copyright licenses, bulletins, newsletters, financial documents, photographs, scrapbooks, and realia.

This collection consists of the records of the Opera Theatre of Rochester, an organization that produced professional opera in Rochester from 1962 to 1999. The materials in this collection include documents, correspondence, slides, photographs and video recordings. Materials in this collection date between 1979 and 2004.

This collection consists of newspaper clippings and legal documents pertaining to the first same-sex couple allowed to adopt children in Monroe County, New York. The materials date between 1993 and 1996.

This collection consists of the papers collected by Pam Barres, a Rochester area LBGTQ advocate. The materials date between 1990 and 1996. The materials consist of newspaper articles regarding same-sex adoption, as well as, newsletters and journals regarding the transgender community.

Consists of the papers of Patricia Coury-Doniger, Rochester, New York based nurse practitioner of infectious diseases and founder of the Center for Community Practice at the University of Rochester. The materials are comprised of slides, books, binders, booklets, correspondence, and articles and are related to the prevention and treatment of STI's, HIV and AIDS, and training materials.